|Gender||season 1-7?=female season 8=male|
|Date of Birth||-|
|First Appearance||You Can't Miss The Bear|
|Last Appearance||All About My Mom|
|Number of episodes||36|
|Relatives|| Celia (mother)|
Dean Hodes (father)
|Portrayed by||Allie Grant|
Isabelle Hodes (now known as Bruce Hodes) is Celia's daughter, who frustrated her mother with her open lesbianism before her sex change. Celia is also frustrated with her daughter's unwillingness to lose weight. That frustration peaks when Isabelle becomes an advertising model for Huskaroo's before her transition, a clothing line for plus-size girls. Isabelle becomes close friends with Shane Botwin in season 3, as they bond over their dysfunctional families. Isabelle resents her mother, but she seems to enjoy her father's company. She is seen throughout season 1 - 5 up until her final appearance in the season 5 finale where she was going to help Doug and Dean get revenge on Celia for stealing their pot. In the series finale, after a ten-year gap, Dean reveals to Shane that Isabelle had a sex change operation and is now named as Bruce.
- Isabelle openly admits she is a lesbian before transitioning.
- While getting high with Shane for the first time, Isabelle lets Shane touch her boobs. Shane offers to let her touch his penis but she has no interest in doing so.
- The subplot of Doug, Dean, and Isabelle teaming up to take down Celia in the season 5 finale would have been explored in season 6 but due to the departure of Elizabeth Perkins (the actress who portrays Celia), Celia and Isabelle were no longer seen in the series since the season 5 finale although they are mentioned a few times.
- Isabelle was said to have had SRS and changed her name to Bruce Hodes.